Answer below questions.
1: (a) Briefly explain the function and the mechanism of action of proprotein convertase subtilisin/Kexin type 9 (PCSK9) and explain how it was initially identified in humans as an attractive target or dyslipidemia drug development. With diagram.
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(b) Describe in detail a pre- clinical strategy for developing compounds that interact with the target using in vitro assays and animal models. Example: PCSK9. Also, the different types of agents being developed to manipulate pcsk9 expression should be discussed.
2: You are a top research scientist in a pharmaceutical company and have been asked to develop a business plan for a novel once per day long acting bronchodilator, targeting the beta2 adrenergic receptor for asthma. Example, Salmeterol.
(a) Indicate the criteria for designing your trial and for the recruitment and screening of individuals prior to them participating in your trial.
(b) Please describe in detail the relevant stages that would need to be undertaken during the drug discovery process.
(c) Indicate a screen sequence detailing how you would evaluate your lead compound prior to your drug entering a clinical trial during the development process.
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